You May Vote Your Proxy When You View The Material On The Internet. You Will Be Asked To Follow The Prompts To Vote Your Shares. LEAP THERAPEUTICS, INC 47 Thorndike Street, Suite B1-1 Cambridge, MA 02141 NOTICE OF ANNUAL MEETING OF SHAREHOLDERS to be held on July 2, 2024 *Shareholders are cordially invited to attend the Annual Meeting and vote in person. At the meeting, you will need to request a ballot to vote your shares. Dear Shareholder, The 2024 Annual Meeting of Shareholders of Leap Therapeutics, Inc. will be conducted virtually over the Internet on July 2, 2024, at 11:30 AM (local time). Proposals to be considered at the Annual Meeting: (1) To consider and act upon a proposal to elect to the Company’s Board of Directors four persons nominated by the Board of Directors; (2) To consider and act upon, by a non-binding advisory vote, a resolution to approve the compensation of our named executive officers; (3) To consider and act upon an amendment to the Leap Therapeutics, Inc. 2022 Equity Incentive Plan; and (4) To consider and act upon a proposal to ratify the appointment of EisnerAmper LLP as the Company’s independent registered public accounting firm for the 2024 fiscal year; ending December 31, 2024. The Board of Directors recommends a vote “FOR” all nominees under Proposal 1, and “FOR” Proposals 2, 3 and 4. .. Your electronic vote authorizes the named proxies to vote your shares in the same manner as if you marked, signed, dated, and returned the proxy card. The Proxy Materials are available for review at: https://www.cstproxy.com/leaptx/2024 CONTROL NUMBER LEAP THERAPEUTICS, INC c/o Continental Proxy Services 1 State Street, New York NY 10004 Vote Your Proxy on the Internet: https://www.cstproxy.com/igi/2022 or https://www.cstproxyvote.com Have your notice available when you access the above website. Follow the prompts to vote your shares. Vote during the Meeting – If you plan to attend the virtual online annual meeting, you will need your 12 digit control number to vote electronically during the annual meeting. To attend the annual meeting, visit: https://www.cstproxy.com/leaptx/2024 MOBILE VOTING On your Smartphone/Tablet, open the QR Reader and scan the below image. Once the voting site is displayed, enter your Control Number from the proxy card and vote your shares.

LEAP THERAPEUTICS, INC. 47 Thorndike Street, Suite B1-1 Cambridge, MA 02141 Important Notice Regarding the Availability of Proxy Materials For the 2024 Annual Meeting of Shareholders to be Held On July 2, 2024 The following Proxy Materials are available to you to review at: https://www.cstproxy.com/leaptx/2024 - the Company’s Annual Report for the year ended December 31, 2023. - the Company’s 2024 Proxy Statement. - the Proxy Card. - any amendments to the foregoing materials that are required to be furnished to shareholders. This is not a ballot. You cannot use this notice to vote your shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. If you would like to receive a paper or e-mail copy of these documents, you must request one. There is no charge for such documents to be mailed to you. Please make your request for a copy as instructed below on or before June 18, 2024 to facilitate a timely delivery. You may also request that you receive paper copies of all future proxy materials from the Company. ACCESSING YOUR PROXY MATERIALS ONLINE Have this notice available when you request a paper copy of the proxy materials or to vote your proxy electronically. You must reference your Control number. REQUESTING A PAPER COPY OF THE PROXY MATERIALS By telephone please call 1-888-266-6791, or By logging on to https://www.cstproxy.com/leaptx/2024 or By email at: proxy@continentalstock.com Please include the company name and your control number in the subject line.